There must be one vSphere Replication Manager appliance for each resource group vCenter Server. For vSphere Replication Manager Server nodes, high availability is achieved with the vSphere HA mechanism. VMware recommends deploying vSphere Replication Manager into the resource vSphere cluster managed by the vCenter Server it is associated with and not to the management cluster. This is because the vSphere Replication Manager automatically registers itself as an extension to the vCenter Server where the appliance is deployed.

vSphere Replication Manager can use the internal vPostgreSQL database or an external Microsoft SQL or Oracle databases. All replication configurations in a paired vCenter Server are stored in the database. From a recoverability perspective, it is therefore important to provide continuous backup of the database. This is more easily accomplished with the external database because only a VMware vSphere Storage APIs – Data Protection based backup mechanism can be used for protection of vPostgreSQL.