Architecting VMware vSAN 6.2 : vSAN Design Overview : 5.6 vSAN Requirements : 5.6.4 Network Requirements : 5.6.4.6 Jumbo Frames
   
5.6.4.6 Jumbo Frames
vSAN supports using jumbo frames for vSAN network transmissions. The environment is supported fully whether or not jumbo frames are employed. The performance gains are often not significant enough to justify the underlying configuration necessary to enable jumbo frames properly on the network.
For this reason, VMware only recommends using jumbo frames for vSAN traffic if the physical environment is already configured to support them, and they are part of the existing design, or if the underlying configuration does not create a significant amount of added complexity to the environment.