vSphere HA and vSAN on the same cluster is fully supported and interoperable, as with traditional datastores, and vSphere HA provides the same level of protection for virtual machines on vSAN datastores. However, this level of protection imposes specific restrictions when vSphere HA and vSAN interact.

In addition, vSAN uses its own logical network. Therefore, when vSAN and vSphere HA are enabled for the same cluster, the HA inter-agent traffic flows over this storage network rather than the management network. vSphere HA uses the management network only when vSAN is disabled. vCenter Server automatically chooses the appropriate network when vSphere HA is configured on a host.