Horizon Pod and Block Design Methodology : 5.1 Deployment Models : 5.1.2 Resource Block
   
5.1.2 Resource Block
Sizing for each tenant resource block may vary, ideally between 4 and 32 hosts (see the following figure). A single resource block is dedicated to a tenant regardless of the management block model.
For both service providers and enterprises alike, vSAN Ready Nodes are ideal and an online configurator (http://vsanreadynode.vmware.com/RN/RN) is available to help select the most suitable vSAN Ready-Node hardware for your environment.
Figure 9. Horizon Resource Block
 
A resource block is delineated by a dedicated vCenter Server, which contain one or more vSphere clusters. While vCenter Server supports up to 10,000 powered-on virtual machines, the Pod and block design methodology divides a Horizon “Pod” into multiple blocks with a maximum of 10,000 concurrent sessions per Pod. Pod and block designs of five blocks (2,000 desktops per block) have proven to be the most effective in meeting manageability requirements and scale.
Note vSphere 6.5 supports up to 64 hosts in a single HA/DRS cluster, and the current supported maximum for Horizon 7 is 32 hosts. If there is a need for a larger cluster size, it is recommended that you contact your VMware representative and file an RPQ (Request for Product Qualification). This is subject to change and is correct as of the date of this document.