Architecting a vSphere Compute Platform : Planning Host Deployment : 6.7 Impact of vSAN
   
6.7 Impact of vSAN
There are two specific areas where the use of vSAN can affect the ESXi system image deployment mechanism chosen by a service provider:
vSAN is not supported on stateless hosts.
Persistent disks in the host server that are employed by the hardware as a boot device cannot be used by vSAN and the other way around.
In a typical vSAN environment, you configure hosts to boot from USB, SD, or other non-persistent storage in order to maximize the number of persistent disk slots available for virtual machine storage. This approach allows you to take full advantage of your vSAN distributed datastore capacity, or at least provide you with the option of increasing vSAN capacity in the future.