The vRealize Operations Manager vApp can be backed up like any virtual machine. Choose a backup product that uses VMware vSphere Storage APIs - Data Protection. Take the cluster offline during backup and back up all nodes at the same time (or before the cluster is brought back online).

Avoid the recalculation time window at night for backups and verify that your backup is completed before the recalculation takes place.

As a design consideration, use a full, not partial, restore operation, and restore the entire cluster, not individual nodes. If vRealize Operations Manager is configured to use HA, the cluster can withstand the loss of any single node and continue to function.